藥物交互作用
Adenovirus types 4 and 7 live + Idarubicin
嚴重程度: 禁忌併用
Adenovirus types 4 and 7 live and Idarubicin: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Idarubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The vaccine strains may also replicate more than intended in an immunocompromised patient, leading to vaccine-related infection.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Idarubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Cytotoxic immunosuppression impairs the immune response and permits uncontrolled replication of live attenuated virus.
處置方式
Do not give live vaccines during chemotherapy; defer vaccination until immune recovery, usually at least 3 months after treatment ends. Use non-live vaccines where available.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Idarubicin 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Idarubicin?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Idarubicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idarubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The vaccine strains may also replicate more than intended in an immunocompromised patient, leading to vaccine-related infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Idarubicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during chemotherapy; defer vaccination until immune recovery, usually at least 3 months after treatment ends. Use non-live vaccines where available.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Belatacept, Cyclophosphamide, Deferiprone. The full list is on the Idarubicin page.
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