藥物交互作用
Alfentanil + Diazepam
嚴重程度: 嚴重
Alfentanil and Diazepam: major interaction.
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
用白話說明這項交互作用的意義
Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression via GABA-A and opioid receptor activity.
處置方式
Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Diazepam 的其他交互作用
常見問題
Can I take Alfentanil with Diazepam?
MediHelp rates the interaction as major. Alfentanil and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with an opioid such as alfentanil increases the risk of profound sedation, respiratory depression, hypotension and death. Benzodiazepines are often combined with alfentanil for anesthesia, which requires dose reduction and monitoring.
How serious is the interaction between Alfentanil and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses and titrate each drug carefully, with continuous monitoring of oxygenation and ventilation. Ensure airway equipment and naloxone or flumazenil are available.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alprazolam, Amobarbital. The full list is on the Diazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
