藥物交互作用
Benzhydrocodone / acetaminophen + Diazepam
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Diazepam: major interaction.
最後更新 來源: US FDA label
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摘要
Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from GABA-A potentiation and mu-opioid agonism.
處置方式
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Diazepam 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Diazepam?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids can cause profound sedation, respiratory depression, coma and death, and this is a boxed warning for opioid products. Benzhydrocodone is a hydrocodone prodrug, so the risk matches other opioids.
How serious is the interaction between Benzhydrocodone / acetaminophen and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and consider naloxone availability.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
