藥物交互作用
Almotriptan + Methylergonovine
嚴重程度: 禁忌併用
Almotriptan and Methylergonovine: contraindicated interaction.
最後更新
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摘要
Methylergonovine is an ergot alkaloid with strong vasoconstrictor activity, and combining it with a triptan can cause prolonged vasospasm. This can lead to ischemia and hypertension.
用白話說明這項交互作用的意義
Almotriptan and Methylergonovine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive vasoconstriction from ergot alkaloid and 5-HT1B/1D agonist effects.
處置方式
Do not use within 24 hours of each other. Use alternative uterotonic or migraine therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Almotriptan 的其他交互作用
常見問題
Can I take Almotriptan with Methylergonovine?
MediHelp rates the interaction as contraindicated. Almotriptan and Methylergonovine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylergonovine is an ergot alkaloid with strong vasoconstrictor activity, and combining it with a triptan can cause prolonged vasospasm. This can lead to ischemia and hypertension.
How serious is the interaction between Almotriptan and Methylergonovine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use within 24 hours of each other. Use alternative uterotonic or migraine therapy.
What other medicines interact with Almotriptan?
MediHelp also lists interactions of Almotriptan with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Eletriptan. The full list is on the Almotriptan page.
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