藥物交互作用
Amifampridine + Galantamine
嚴重程度: 中度
Amifampridine and Galantamine: moderate interaction.
最後更新
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摘要
Both drugs increase cholinergic transmission, by cholinesterase inhibition and by potassium channel blockade with enhanced acetylcholine release respectively. Combined use may produce additive cholinergic effects such as abdominal cramping, diarrhea, salivation, bradycardia and bronchospasm. Amifampridine also lowers seizure threshold.
用白話說明這項交互作用的意義
Amifampridine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
為什麼會發生
Additive cholinergic effect: increased acetylcholine release plus reduced acetylcholine breakdown.
處置方式
Monitor for cholinergic adverse effects, heart rate and seizures, and reduce one agent if symptoms occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Galantamine 的其他交互作用
Amifampridine 的其他交互作用
常見問題
Can I take Amifampridine with Galantamine?
MediHelp rates the interaction as moderate. Amifampridine and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase cholinergic transmission, by cholinesterase inhibition and by potassium channel blockade with enhanced acetylcholine release respectively. Combined use may produce additive cholinergic effects such as abdominal cramping, diarrhea, salivation, bradycardia and bronchospasm. Amifampridine also lowers seizure threshold.
How serious is the interaction between Amifampridine and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects, heart rate and seizures, and reduce one agent if symptoms occur.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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