藥物交互作用
Galantamine + Physostigmine
嚴重程度: 嚴重
Galantamine and Physostigmine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both drugs inhibit cholinesterase, so combined use produces additive cholinergic stimulation. This may cause bradycardia, bronchospasm, excessive secretions, vomiting and seizures.
用白話說明這項交互作用的意義
Galantamine and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive acetylcholinesterase inhibition.
處置方式
Avoid concurrent use unless physostigmine is needed for anticholinergic toxicity, with continuous monitoring of heart rate and respiration and atropine available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Galantamine 的其他交互作用
常見問題
Can I take Galantamine with Physostigmine?
MediHelp rates the interaction as major. Galantamine and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit cholinesterase, so combined use produces additive cholinergic stimulation. This may cause bradycardia, bronchospasm, excessive secretions, vomiting and seizures.
How serious is the interaction between Galantamine and Physostigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless physostigmine is needed for anticholinergic toxicity, with continuous monitoring of heart rate and respiration and atropine available.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Ponesimod, Rivastigmine. The full list is on the Galantamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
