藥物交互作用
Amlodipine-olmesartan + Captopril
嚴重程度: 嚴重
Amlodipine-olmesartan and Captopril: major interaction.
最後更新
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摘要
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a proven cardiovascular benefit in most patients.
用白話說明這項交互作用的意義
Amlodipine-olmesartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan belongs to Cardiovascular; Captopril belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, reducing glomerular filtration pressure and aldosterone-mediated potassium excretion.
處置方式
Avoid the combination and use a single RAS blocker with amlodipine. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-olmesartan 的其他交互作用
Captopril 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan with Captopril?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Captopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a proven cardiovascular benefit in most patients.
How serious is the interaction between Amlodipine-olmesartan and Captopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single RAS blocker with amlodipine. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
