藥物交互作用
Captopril + Sacubitril-valsartan
嚴重程度: 禁忌併用
Captopril and Sacubitril-valsartan: contraindicated interaction.
最後更新
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摘要
Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor captopril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.
用白話說明這項交互作用的意義
Captopril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Captopril belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
為什麼會發生
Neprilysin plus ACE inhibition causes additive bradykinin accumulation
處置方式
Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Sacubitril-valsartan 的其他交互作用
Captopril 的其他交互作用
常見問題
Can I take Captopril with Sacubitril-valsartan?
MediHelp rates the interaction as contraindicated. Captopril and Sacubitril-valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin and so increases bradykinin, as does the ACE inhibitor captopril. Combined, the rise in bradykinin substantially increases the risk of angioedema, which can involve the airway.
How serious is the interaction between Captopril and Sacubitril-valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated: stop the ACE inhibitor at least 36 hours before starting sacubitril/valsartan and do not restart one within 36 hours of the other.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Enalapril. The full list is on the Sacubitril-valsartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
