藥物交互作用
Amobarbital + Baclofen
嚴重程度: 嚴重
Amobarbital and Baclofen: major interaction.
最後更新
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摘要
Amobarbital and baclofen together produce additive CNS and respiratory depression, with a risk of profound sedation. Barbiturates may also lower the seizure threshold on baclofen withdrawal, complicating management.
用白話說明這項交互作用的意義
Amobarbital and Baclofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Baclofen belongs to Musculoskeletal.
為什麼會發生
Additive CNS depression from GABA-B agonism by baclofen and GABA-A potentiation by amobarbital.
處置方式
Avoid combining where possible; if necessary use reduced doses and monitor sedation level and respiratory rate. Do not stop baclofen abruptly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Baclofen 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Baclofen?
MediHelp rates the interaction as major. Amobarbital and Baclofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital and baclofen together produce additive CNS and respiratory depression, with a risk of profound sedation. Barbiturates may also lower the seizure threshold on baclofen withdrawal, complicating management.
How serious is the interaction between Amobarbital and Baclofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary use reduced doses and monitor sedation level and respiratory rate. Do not stop baclofen abruptly.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Baclofen page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
