藥物交互作用
Amobarbital + Isavuconazonium
嚴重程度: 禁忌併用
Amobarbital and Isavuconazonium: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
用白話說明這項交互作用的意義
Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
為什麼會發生
Barbiturate-mediated CYP3A4 induction increases isavuconazole clearance.
處置方式
Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amobarbital 的其他交互作用
Isavuconazonium 的其他交互作用
常見問題
Can I take Amobarbital with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
How serious is the interaction between Amobarbital and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
