藥物交互作用
Amobarbital + Warfarin
嚴重程度: 嚴重
Amobarbital and Warfarin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates induce hepatic enzymes and accelerate warfarin metabolism, lowering INR and reducing anticoagulant protection. The effect develops over weeks and persists after the barbiturate is stopped, with risk of rebound overanticoagulation.
用白話說明這項交互作用的意義
Amobarbital and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
為什麼會發生
Induction of hepatic CYP enzymes (including CYP2C9 and CYP3A4) increasing warfarin clearance.
處置方式
Monitor INR frequently and increase the warfarin dose as required. Reduce the dose and recheck INR when the barbiturate is discontinued.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Warfarin 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Warfarin?
MediHelp rates the interaction as major. Amobarbital and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and accelerate warfarin metabolism, lowering INR and reducing anticoagulant protection. The effect develops over weeks and persists after the barbiturate is stopped, with risk of rebound overanticoagulation.
How serious is the interaction between Amobarbital and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently and increase the warfarin dose as required. Reduce the dose and recheck INR when the barbiturate is discontinued.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
