藥物交互作用
Amoxapine + Linezolid
嚴重程度: 禁忌併用
Amoxapine and Linezolid: contraindicated interaction.
最後更新
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摘要
Linezolid is a reversible nonselective MAO inhibitor and amoxapine inhibits serotonin and norepinephrine reuptake. Together they can precipitate serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability.
用白話說明這項交互作用的意義
Amoxapine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive serotonergic and noradrenergic effects from MAO inhibition plus reuptake inhibition.
處置方式
Avoid the combination and choose another antibiotic. If linezolid is essential, stop amoxapine and monitor closely for serotonin toxicity.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Linezolid 的其他交互作用
常見問題
Can I take Amoxapine with Linezolid?
MediHelp rates the interaction as contraindicated. Amoxapine and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible nonselective MAO inhibitor and amoxapine inhibits serotonin and norepinephrine reuptake. Together they can precipitate serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability.
How serious is the interaction between Amoxapine and Linezolid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If linezolid is essential, stop amoxapine and monitor closely for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Atomoxetine, Benzphetamine, Brimonidine. The full list is on the Linezolid page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
