藥物交互作用
Anagrelide + Memantine-donepezil
嚴重程度: 嚴重
Anagrelide and Memantine-donepezil: major interaction.
最後更新
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摘要
Both donepezil and anagrelide can prolong the QT interval, increasing the risk of ventricular arrhythmias including torsades de pointes. Anagrelide can also cause tachycardia and palpitations.
用白話說明這項交互作用的意義
Anagrelide and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation.
處置方式
Avoid if possible. If coadministered, obtain a baseline ECG, monitor periodically and keep potassium and magnesium normal.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Memantine-donepezil 的其他交互作用
Anagrelide 的其他交互作用
常見問題
Can I take Anagrelide with Memantine-donepezil?
MediHelp rates the interaction as major. Anagrelide and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both donepezil and anagrelide can prolong the QT interval, increasing the risk of ventricular arrhythmias including torsades de pointes. Anagrelide can also cause tachycardia and palpitations.
How serious is the interaction between Anagrelide and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministered, obtain a baseline ECG, monitor periodically and keep potassium and magnesium normal.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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