藥物交互作用
Dronedarone + Memantine-donepezil
嚴重程度: 禁忌併用
Dronedarone and Memantine-donepezil: contraindicated interaction.
最後更新
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摘要
Dronedarone prolongs the QTc interval, and the donepezil component prolongs the QTc interval through cardiac potassium-channel effects and can cause bradycardia. Combined use adds to the risk of torsades de pointes and sudden cardiac death.
用白話說明這項交互作用的意義
Dronedarone and Memantine-donepezil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Memantine-donepezil belongs to Central Nervous System.
為什麼會發生
Additive QTc prolongation (pharmacodynamic)
處置方式
Do not co-administer; choose an alternative that does not prolong the QT interval.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Memantine-donepezil 的其他交互作用
Dronedarone 的其他交互作用
常見問題
Can I take Dronedarone with Memantine-donepezil?
MediHelp rates the interaction as contraindicated. Dronedarone and Memantine-donepezil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone prolongs the QTc interval, and the donepezil component prolongs the QTc interval through cardiac potassium-channel effects and can cause bradycardia. Combined use adds to the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Dronedarone and Memantine-donepezil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Thioridazine, Amantadine, Amiodarone. The full list is on the Memantine-donepezil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
