藥物交互作用
Armodafinil + Avapritinib
嚴重程度: 嚴重
Armodafinil and Avapritinib: major interaction.
最後更新
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摘要
Armodafinil may lower avapritinib exposure through CYP3A4 induction, reducing efficacy. Labeling advises avoiding moderate and strong CYP3A inducers.
用白話說明這項交互作用的意義
Armodafinil and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Avapritinib belongs to Oncology.
為什麼會發生
Armodafinil induces CYP3A4, increasing avapritinib metabolism.
處置方式
Avoid the combination and use a non-inducing alternative for wakefulness.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Armodafinil 的其他交互作用
Avapritinib 的其他交互作用
常見問題
Can I take Armodafinil with Avapritinib?
MediHelp rates the interaction as major. Armodafinil and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower avapritinib exposure through CYP3A4 induction, reducing efficacy. Labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Armodafinil and Avapritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative for wakefulness.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Cyclosporine, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
