Drug interactions
Armodafinil + Avapritinib
Severity: Major
Armodafinil and Avapritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may lower avapritinib exposure through CYP3A4 induction, reducing efficacy. Labeling advises avoiding moderate and strong CYP3A inducers.
What this interaction means in plain words
Armodafinil and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, increasing avapritinib metabolism.
What to do
Avoid the combination and use a non-inducing alternative for wakefulness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Other interactions of Avapritinib
Frequently asked questions
Can I take Armodafinil with Avapritinib?
MediHelp rates the interaction as major. Armodafinil and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower avapritinib exposure through CYP3A4 induction, reducing efficacy. Labeling advises avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Armodafinil and Avapritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative for wakefulness.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Cyclosporine, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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