藥物交互作用
Asenapine + Encorafenib
嚴重程度: 嚴重
Asenapine and Encorafenib: major interaction.
最後更新
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摘要
Encorafenib can prolong the QTc interval in a dose-dependent manner, and asenapine has a similar effect. Used together they may increase the risk of torsades de pointes.
用白話說明這項交互作用的意義
Asenapine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Encorafenib belongs to Oncology.
為什麼會發生
Additive QT interval prolongation.
處置方式
Avoid the combination where possible. If it is needed, monitor ECG and electrolytes at baseline and periodically, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Asenapine 的其他交互作用
Encorafenib 的其他交互作用
常見問題
Can I take Asenapine with Encorafenib?
MediHelp rates the interaction as major. Asenapine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib can prolong the QTc interval in a dose-dependent manner, and asenapine has a similar effect. Used together they may increase the risk of torsades de pointes.
How serious is the interaction between Asenapine and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, monitor ECG and electrolytes at baseline and periodically, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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