藥物交互作用
Aspirin rectal + Edoxaban
嚴重程度: 嚴重
Aspirin rectal and Edoxaban: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Rectal aspirin is absorbed systemically and inhibits platelets, so combined use with edoxaban raises bleeding risk. Rectal mucosal irritation may also add to local bleeding.
用白話說明這項交互作用的意義
Aspirin rectal and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive pharmacodynamic effect: factor Xa inhibition plus platelet COX-1 inhibition.
處置方式
Avoid unless there is a clear indication and monitor for bleeding. Use the lowest effective aspirin dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Edoxaban 的其他交互作用
常見問題
Can I take Aspirin rectal with Edoxaban?
MediHelp rates the interaction as major. Aspirin rectal and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rectal aspirin is absorbed systemically and inhibits platelets, so combined use with edoxaban raises bleeding risk. Rectal mucosal irritation may also add to local bleeding.
How serious is the interaction between Aspirin rectal and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless there is a clear indication and monitor for bleeding. Use the lowest effective aspirin dose.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
