藥物交互作用
Atazanavir + Lansoprazole
嚴重程度: 嚴重
Atazanavir and Lansoprazole: major interaction.
最後更新
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摘要
Atazanavir absorption depends on gastric acidity, and lansoprazole markedly lowers atazanavir concentrations. This risks loss of virologic suppression and development of resistance.
用白話說明這項交互作用的意義
Atazanavir and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Lansoprazole belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH decreases atazanavir solubility and hence absorption.
處置方式
Avoid PPIs in treatment-experienced patients on atazanavir. In treatment-naive patients, follow labeling for a low PPI dose taken about 12 hours before ritonavir-boosted atazanavir, or use an alternative antiretroviral.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lansoprazole 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Lansoprazole?
MediHelp rates the interaction as major. Atazanavir and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir absorption depends on gastric acidity, and lansoprazole markedly lowers atazanavir concentrations. This risks loss of virologic suppression and development of resistance.
How serious is the interaction between Atazanavir and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients on atazanavir. In treatment-naive patients, follow labeling for a low PPI dose taken about 12 hours before ritonavir-boosted atazanavir, or use an alternative antiretroviral.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
