藥物交互作用
Atenolol-chlorthalidone + Carbenoxolone
嚴重程度: 嚴重
Atenolol-chlorthalidone and Carbenoxolone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Carbenoxolone causes mineralocorticoid-like sodium and water retention and potassium loss, which can raise blood pressure and oppose the antihypertensive effect. Combined with chlorthalidone, the risk of hypokalemia is considerably increased.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid excess that adds to thiazide-induced potassium wasting and counteracts antihypertensive therapy.
處置方式
Avoid the combination where possible; if used, monitor serum potassium and blood pressure regularly and correct hypokalemia promptly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atenolol-chlorthalidone 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Carbenoxolone?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone causes mineralocorticoid-like sodium and water retention and potassium loss, which can raise blood pressure and oppose the antihypertensive effect. Combined with chlorthalidone, the risk of hypokalemia is considerably increased.
How serious is the interaction between Atenolol-chlorthalidone and Carbenoxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and blood pressure regularly and correct hypokalemia promptly.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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