藥物交互作用
Basiliximab + Brexucabtagene autoleucel
嚴重程度: 嚴重
Basiliximab and Brexucabtagene autoleucel: major interaction.
最後更新
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摘要
Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
用白話說明這項交互作用的意義
Basiliximab and Brexucabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Brexucabtagene autoleucel belongs to Oncology.
為什麼會發生
Pharmacodynamic antagonism of CAR T-cell proliferation through IL-2 receptor blockade and additive immunosuppression.
處置方式
Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Basiliximab 的其他交互作用
- Basiliximab + Bcg vaccine live 禁忌併用
- Basiliximab + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Basiliximab + Measles mumps and rubella vaccine 禁忌併用
- Basiliximab + Measles mumps and rubella vaccine live 禁忌併用
- Basiliximab + Measles mumps rubella and varicella vaccine live 禁忌併用
- Basiliximab + Measles vaccine 禁忌併用
Brexucabtagene autoleucel 的其他交互作用
常見問題
Can I take Basiliximab with Brexucabtagene autoleucel?
MediHelp rates the interaction as major. Basiliximab and Brexucabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
How serious is the interaction between Basiliximab and Brexucabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
