藥物交互作用
Azathioprine + Brexucabtagene autoleucel
嚴重程度: 嚴重
Azathioprine and Brexucabtagene autoleucel: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Azathioprine may impair T-cell function and compromise CAR-T expansion and efficacy. It also compounds the infection risk of CAR-T therapy.
用白話說明這項交互作用的意義
Azathioprine and Brexucabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Brexucabtagene autoleucel belongs to Oncology.
為什麼會發生
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
處置方式
Stop azathioprine before leukapheresis and infusion in line with the treating center protocol. Monitor for infection if it is continued.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azathioprine 的其他交互作用
Brexucabtagene autoleucel 的其他交互作用
常見問題
Can I take Azathioprine with Brexucabtagene autoleucel?
MediHelp rates the interaction as major. Azathioprine and Brexucabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and compromise CAR-T expansion and efficacy. It also compounds the infection risk of CAR-T therapy.
How serious is the interaction between Azathioprine and Brexucabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop azathioprine before leukapheresis and infusion in line with the treating center protocol. Monitor for infection if it is continued.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
