藥物交互作用
Basiliximab + Lisocabtagene maraleucel
嚴重程度: 嚴重
Basiliximab and Lisocabtagene maraleucel: major interaction.
最後更新
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摘要
Lisocabtagene maraleucel is a CAR T-cell therapy that depends on functional T-cell expansion, while basiliximab inhibits activated T cells through IL-2 receptor blockade. Combined use may reduce CAR T-cell efficacy and adds to infection risk in an already immunocompromised patient.
用白話說明這項交互作用的意義
Basiliximab and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Lisocabtagene maraleucel belongs to Oncology.
為什麼會發生
Basiliximab blocks CD25 on activated T cells, which may impair CAR T-cell proliferation and persistence, with additive immunosuppression.
處置方式
Avoid basiliximab around CAR T-cell infusion unless essential, and choose alternative approaches where possible. If used, monitor closely for infection and for loss of CAR T-cell response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Basiliximab 的其他交互作用
- Basiliximab + Bcg vaccine live 禁忌併用
- Basiliximab + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Basiliximab + Measles mumps and rubella vaccine 禁忌併用
- Basiliximab + Measles mumps and rubella vaccine live 禁忌併用
- Basiliximab + Measles mumps rubella and varicella vaccine live 禁忌併用
- Basiliximab + Measles vaccine 禁忌併用
Lisocabtagene maraleucel 的其他交互作用
常見問題
Can I take Basiliximab with Lisocabtagene maraleucel?
MediHelp rates the interaction as major. Basiliximab and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisocabtagene maraleucel is a CAR T-cell therapy that depends on functional T-cell expansion, while basiliximab inhibits activated T cells through IL-2 receptor blockade. Combined use may reduce CAR T-cell efficacy and adds to infection risk in an already immunocompromised patient.
How serious is the interaction between Basiliximab and Lisocabtagene maraleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid basiliximab around CAR T-cell infusion unless essential, and choose alternative approaches where possible. If used, monitor closely for infection and for loss of CAR T-cell response.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
