藥物交互作用
Azathioprine + Lisocabtagene maraleucel
嚴重程度: 嚴重
Azathioprine and Lisocabtagene maraleucel: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of lisocabtagene maraleucel. Together they also increase susceptibility to serious infection.
用白話說明這項交互作用的意義
Azathioprine and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Lisocabtagene maraleucel belongs to Oncology.
為什麼會發生
Antimetabolite-driven lymphocyte suppression may blunt CAR T-cell proliferation, and the effects add to the immune deficiency caused by the therapy.
處置方式
Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azathioprine 的其他交互作用
Lisocabtagene maraleucel 的其他交互作用
常見問題
Can I take Azathioprine with Lisocabtagene maraleucel?
MediHelp rates the interaction as major. Azathioprine and Lisocabtagene maraleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair CAR T-cell expansion and persistence, potentially reducing efficacy of lisocabtagene maraleucel. Together they also increase susceptibility to serious infection.
How serious is the interaction between Azathioprine and Lisocabtagene maraleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid azathioprine around lymphodepletion and CAR T infusion unless essential, and follow the product labeling for washout. Monitor closely for infection and cytopenias if it must be used.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
