藥物交互作用
Bcg vaccine live + Leflunomide
嚴重程度: 禁忌併用
Bcg vaccine live and Leflunomide: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
用白話說明這項交互作用的意義
Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Suppressed lymphocyte function impairs control of live attenuated organisms.
處置方式
Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Leflunomide 的其他交互作用
常見問題
Can I take Bcg vaccine live with Leflunomide?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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