藥物交互作用
Belzutifan + Ethinyl estradiol-drospirenone
嚴重程度: 嚴重
Belzutifan and Ethinyl estradiol-drospirenone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Belzutifan can reduce exposure to hormonal contraceptives, which may cause contraceptive failure or breakthrough bleeding. This matters because belzutifan can cause fetal harm.
用白話說明這項交互作用的意義
Belzutifan and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Belzutifan belongs to Miscellaneous; Ethinyl estradiol-drospirenone belongs to Endocrine.
為什麼會發生
Belzutifan induces CYP3A4, increasing metabolism of ethinyl estradiol and drospirenone.
處置方式
Use an effective non-hormonal contraceptive method during treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraception alone.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ethinyl estradiol-drospirenone 的其他交互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-drospirenone + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-drospirenone 嚴重
- Amobarbital + Ethinyl estradiol-drospirenone 嚴重
Belzutifan 的其他交互作用
常見問題
Can I take Belzutifan with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as major. Belzutifan and Ethinyl estradiol-drospirenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Belzutifan can reduce exposure to hormonal contraceptives, which may cause contraceptive failure or breakthrough bleeding. This matters because belzutifan can cause fetal harm.
How serious is the interaction between Belzutifan and Ethinyl estradiol-drospirenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during treatment and for the period specified in labeling after the last dose. Do not rely on hormonal contraception alone.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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