藥物交互作用
Benzhydrocodone / acetaminophen + Clorazepate
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Clorazepate: major interaction.
最後更新
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摘要
Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. The risk is dose-dependent and is regulated by boxed warnings.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from opioid and benzodiazepine receptor effects.
處置方式
Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clorazepate 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Clorazepate?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. The risk is dose-dependent and is regulated by boxed warnings.
How serious is the interaction between Benzhydrocodone / acetaminophen and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
