藥物交互作用
Belladonna and opium + Clorazepate
嚴重程度: 嚴重
Belladonna and opium and Clorazepate: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
The opium component adds opioid effects to the benzodiazepine, risking profound sedation, respiratory depression and death. Belladonna alkaloids add anticholinergic confusion.
用白話說明這項交互作用的意義
Belladonna and opium and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A potentiation.
處置方式
Avoid combining where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiratory status and sedation. Counsel patients and caregivers on warning signs of overdose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clorazepate 的其他交互作用
常見問題
Can I take Belladonna and opium with Clorazepate?
MediHelp rates the interaction as major. Belladonna and opium and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds opioid effects to the benzodiazepine, risking profound sedation, respiratory depression and death. Belladonna alkaloids add anticholinergic confusion.
How serious is the interaction between Belladonna and opium and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary, use the lowest effective doses for the shortest duration and monitor respiratory status and sedation. Counsel patients and caregivers on warning signs of overdose.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
