藥物交互作用
Benzhydrocodone / acetaminophen + Esketamine
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Esketamine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Benzhydrocodone is a prodrug of hydrocodone, an opioid. With esketamine, risks of profound sedation and respiratory depression increase.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression between an opioid and esketamine.
處置方式
Avoid unnecessary co-use; if required, use the lowest effective opioid dose and monitor sedation and respiratory rate after esketamine administration.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Esketamine 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Esketamine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, an opioid. With esketamine, risks of profound sedation and respiratory depression increase.
How serious is the interaction between Benzhydrocodone / acetaminophen and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-use; if required, use the lowest effective opioid dose and monitor sedation and respiratory rate after esketamine administration.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
