藥物交互作用
Buprenorphine long-acting + Esketamine
嚴重程度: 嚴重
Buprenorphine long-acting and Esketamine: major interaction.
最後更新
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摘要
Esketamine and opioids can each cause sedation and dissociation, and together they may increase CNS and respiratory depression. Long-acting buprenorphine provides continuous exposure, so effects can overlap with each esketamine session.
用白話說明這項交互作用的意義
Buprenorphine long-acting and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression.
處置方式
Monitor sedation, oxygen saturation, and breathing throughout the post-dose observation period. Use only when alternatives are inadequate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Esketamine 的其他交互作用
常見問題
Can I take Buprenorphine long-acting with Esketamine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esketamine and opioids can each cause sedation and dissociation, and together they may increase CNS and respiratory depression. Long-acting buprenorphine provides continuous exposure, so effects can overlap with each esketamine session.
How serious is the interaction between Buprenorphine long-acting and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, oxygen saturation, and breathing throughout the post-dose observation period. Use only when alternatives are inadequate.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
