藥物交互作用
Bethanechol + Physostigmine
嚴重程度: 嚴重
Bethanechol and Physostigmine: major interaction.
最後更新
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摘要
Physostigmine inhibits cholinesterase and increases acetylcholine, adding to the direct muscarinic stimulation of bethanechol. This can cause marked cholinergic toxicity including bradycardia, bronchospasm, salivation, vomiting and cramping.
用白話說明這項交互作用的意義
Bethanechol and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive cholinergic effect from direct muscarinic agonism plus inhibition of acetylcholine breakdown.
處置方式
Avoid the combination where possible. If used, monitor heart rate, respiratory status and gastrointestinal symptoms, and have atropine available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bethanechol 的其他交互作用
常見問題
Can I take Bethanechol with Physostigmine?
MediHelp rates the interaction as major. Bethanechol and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Physostigmine inhibits cholinesterase and increases acetylcholine, adding to the direct muscarinic stimulation of bethanechol. This can cause marked cholinergic toxicity including bradycardia, bronchospasm, salivation, vomiting and cramping.
How serious is the interaction between Bethanechol and Physostigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor heart rate, respiratory status and gastrointestinal symptoms, and have atropine available.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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