藥物交互作用
Amitriptyline + Bethanechol
嚴重程度: 中度
Amitriptyline and Bethanechol: moderate interaction.
最後更新
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摘要
Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.
用白話說明這項交互作用的意義
Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Bethanechol belongs to Gastrointestinal Tract.
為什麼會發生
Pharmacodynamic antagonism between a muscarinic agonist and a muscarinic antagonist.
處置方式
Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bethanechol 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Bethanechol?
MediHelp rates the interaction as moderate. Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.
How serious is the interaction between Amitriptyline and Bethanechol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
