藥物交互作用
Bleomycin + Brentuximab vedotin
嚴重程度: 禁忌併用
Bleomycin and Brentuximab vedotin: contraindicated interaction.
最後更新
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摘要
Concomitant use with bleomycin led to excess pulmonary toxicity in Hodgkin lymphoma patients, and this combination is contraindicated in the brentuximab labeling. Patients may develop pneumonitis or respiratory failure.
用白話說明這項交互作用的意義
Bleomycin and Brentuximab vedotin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bleomycin belongs to Oncology; Brentuximab vedotin belongs to Oncology.
為什麼會發生
Additive or synergistic lung injury; the exact mechanism is not fully established.
處置方式
Do not combine; omit bleomycin from regimens containing brentuximab vedotin (for example AVD with brentuximab). Evaluate any new cough or dyspnea promptly.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Bleomycin 的其他交互作用
Brentuximab vedotin 的其他交互作用
常見問題
Can I take Bleomycin with Brentuximab vedotin?
MediHelp rates the interaction as contraindicated. Bleomycin and Brentuximab vedotin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concomitant use with bleomycin led to excess pulmonary toxicity in Hodgkin lymphoma patients, and this combination is contraindicated in the brentuximab labeling. Patients may develop pneumonitis or respiratory failure.
How serious is the interaction between Bleomycin and Brentuximab vedotin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; omit bleomycin from regimens containing brentuximab vedotin (for example AVD with brentuximab). Evaluate any new cough or dyspnea promptly.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Dengue vaccine. The full list is on the Bleomycin page.
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