藥物交互作用
Brigatinib + Enzalutamide
嚴重程度: 嚴重
Brigatinib and Enzalutamide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Enzalutamide reduces brigatinib exposure through enzyme induction. Reduced exposure may compromise control of ALK-positive lung cancer.
用白話說明這項交互作用的意義
Brigatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Enzalutamide belongs to Endocrine.
為什麼會發生
CYP3A4 induction by enzalutamide increases brigatinib clearance.
處置方式
Avoid concurrent use. If a strong inducer cannot be avoided, brigatinib labeling advises increasing the dose in stepwise fashion and reducing it again after the inducer is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Enzalutamide 的其他交互作用
Brigatinib 的其他交互作用
常見問題
Can I take Brigatinib with Enzalutamide?
MediHelp rates the interaction as major. Brigatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide reduces brigatinib exposure through enzyme induction. Reduced exposure may compromise control of ALK-positive lung cancer.
How serious is the interaction between Brigatinib and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a strong inducer cannot be avoided, brigatinib labeling advises increasing the dose in stepwise fashion and reducing it again after the inducer is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
