藥物交互作用
Apalutamide + Brigatinib
嚴重程度: 嚴重
Apalutamide and Brigatinib: major interaction.
最後更新
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摘要
Brigatinib is metabolized mainly by CYP3A4, and apalutamide strongly induces this enzyme. Lower brigatinib exposure may reduce efficacy in ALK-positive lung cancer.
用白話說明這項交互作用的意義
Apalutamide and Brigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Brigatinib belongs to Oncology.
為什麼會發生
Apalutamide induces CYP3A4, increasing brigatinib clearance.
處置方式
Avoid concurrent use. If unavoidable, increase the brigatinib dose per labeling guidance for strong inducers and monitor response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Brigatinib 的其他交互作用
常見問題
Can I take Apalutamide with Brigatinib?
MediHelp rates the interaction as major. Apalutamide and Brigatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brigatinib is metabolized mainly by CYP3A4, and apalutamide strongly induces this enzyme. Lower brigatinib exposure may reduce efficacy in ALK-positive lung cancer.
How serious is the interaction between Apalutamide and Brigatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If unavoidable, increase the brigatinib dose per labeling guidance for strong inducers and monitor response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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