藥物交互作用
Brompheniramine + Calcium / magnesium / potassium / sodium oxybates
嚴重程度: 嚴重
Brompheniramine and Calcium / magnesium / potassium / sodium oxybates: major interaction.
最後更新 來源: US FDA label
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摘要
Oxybates strongly depress the CNS, and a sedating antihistamine adds to this effect. Profound sedation, respiratory depression, and coma are possible.
用白話說明這項交互作用的意義
Brompheniramine and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression through pharmacodynamic synergism.
處置方式
Avoid sedating antihistamines and use a non-sedating alternative. If unavoidable, use minimum doses and monitor for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Brompheniramine 的其他交互作用
常見問題
Can I take Brompheniramine with Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates the interaction as major. Brompheniramine and Calcium / magnesium / potassium / sodium oxybates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates strongly depress the CNS, and a sedating antihistamine adds to this effect. Profound sedation, respiratory depression, and coma are possible.
How serious is the interaction between Brompheniramine and Calcium / magnesium / potassium / sodium oxybates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sedating antihistamines and use a non-sedating alternative. If unavoidable, use minimum doses and monitor for sedation and respiratory depression.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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