藥物交互作用
Brompheniramine + Dipipanone
嚴重程度: 嚴重
Brompheniramine and Dipipanone: major interaction.
最後更新 來源: US FDA label
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摘要
Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
用白話說明這項交互作用的意義
Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression via opioid agonism and H1 antagonism.
處置方式
Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Brompheniramine 的其他交互作用
常見問題
Can I take Brompheniramine with Dipipanone?
MediHelp rates the interaction as major. Brompheniramine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid, and a sedating antihistamine increases the risk of excessive sedation and respiratory depression.
How serious is the interaction between Brompheniramine and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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