藥物交互作用
Buprenorphine transdermal + Orphenadrin
嚴重程度: 嚴重
Buprenorphine transdermal and Orphenadrin: major interaction.
最後更新
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摘要
Orphenadrine is sedating and anticholinergic, and buprenorphine is an opioid with respiratory depressant potential. Together they may cause additive sedation and respiratory depression.
用白話說明這項交互作用的意義
Buprenorphine transdermal and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS depression.
處置方式
Use only if alternatives are inadequate, at the lowest effective doses. Monitor for sedation and slowed breathing, particularly at initiation and dose changes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Orphenadrin 的其他交互作用
常見問題
Can I take Buprenorphine transdermal with Orphenadrin?
MediHelp rates the interaction as major. Buprenorphine transdermal and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine is sedating and anticholinergic, and buprenorphine is an opioid with respiratory depressant potential. Together they may cause additive sedation and respiratory depression.
How serious is the interaction between Buprenorphine transdermal and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate, at the lowest effective doses. Monitor for sedation and slowed breathing, particularly at initiation and dose changes.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
