藥物交互作用
Butabarbital + Lorlatinib
嚴重程度: 禁忌併用
Butabarbital and Lorlatinib: contraindicated interaction.
最後更新
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摘要
Butabarbital is a barbiturate that induces CYP3A4. Strong CYP3A inducers markedly lower lorlatinib exposure and caused liver enzyme elevations in a study with rifampin, so efficacy may be lost.
用白話說明這項交互作用的意義
Butabarbital and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Induction of CYP3A4 increases lorlatinib metabolism and lowers its plasma concentrations.
處置方式
Avoid the combination and use a non-inducing sedative. Allow the inducer to wash out before starting lorlatinib.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lorlatinib 的其他交互作用
常見問題
Can I take Butabarbital with Lorlatinib?
MediHelp rates the interaction as contraindicated. Butabarbital and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Butabarbital is a barbiturate that induces CYP3A4. Strong CYP3A inducers markedly lower lorlatinib exposure and caused liver enzyme elevations in a study with rifampin, so efficacy may be lost.
How serious is the interaction between Butabarbital and Lorlatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing sedative. Allow the inducer to wash out before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Lorlatinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
