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Enzalutamide + Lorlatinib

嚴重程度: 禁忌併用

Enzalutamide and Lorlatinib: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Enzalutamide is a strong CYP3A4 inducer and substantially lowers lorlatinib exposure, with a risk of loss of efficacy and liver enzyme elevations. Strong inducers are contraindicated with lorlatinib.

用白話說明這項交互作用的意義

Enzalutamide and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Enzalutamide belongs to Endocrine; Lorlatinib belongs to Oncology.

證據等級: Moderate

為什麼會發生

Strong CYP3A4 induction lowering lorlatinib levels

處置方式

Do not combine; choose an alternative antiandrogen or ALK inhibitor.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Enzalutamide 與 Lorlatinib 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
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常見問題

Can I take Enzalutamide with Lorlatinib?

MediHelp rates the interaction as contraindicated. Enzalutamide and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Enzalutamide is a strong CYP3A4 inducer and substantially lowers lorlatinib exposure, with a risk of loss of efficacy and liver enzyme elevations. Strong inducers are contraindicated with lorlatinib.

How serious is the interaction between Enzalutamide and Lorlatinib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative antiandrogen or ALK inhibitor.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.

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