藥物交互作用
Cabozantinib + Itraconazole
嚴重程度: 嚴重
Cabozantinib and Itraconazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Itraconazole increases cabozantinib exposure, which may worsen diarrhea, hypertension, hand-foot syndrome, hemorrhage and hepatotoxicity.
用白話說明這項交互作用的意義
Cabozantinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
為什麼會發生
Itraconazole strongly inhibits CYP3A4, which metabolizes cabozantinib.
處置方式
Avoid the combination if possible. If a strong inhibitor is required, reduce the cabozantinib dose per labeling and resume the earlier dose 2-3 days after stopping itraconazole.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Itraconazole 的其他交互作用
Cabozantinib 的其他交互作用
常見問題
Can I take Cabozantinib with Itraconazole?
MediHelp rates the interaction as major. Cabozantinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases cabozantinib exposure, which may worsen diarrhea, hypertension, hand-foot syndrome, hemorrhage and hepatotoxicity.
How serious is the interaction between Cabozantinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If a strong inhibitor is required, reduce the cabozantinib dose per labeling and resume the earlier dose 2-3 days after stopping itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
