藥物交互作用
Cabozantinib + Clarithromycin
嚴重程度: 嚴重
Cabozantinib and Clarithromycin: major interaction.
最後更新
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摘要
Clarithromycin raises cabozantinib exposure through CYP3A4 inhibition, which may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
用白話說明這項交互作用的意義
Cabozantinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of cabozantinib.
處置方式
Avoid if possible and use a non-CYP3A4-inhibiting antibiotic. If required, reduce the cabozantinib dose per labeling and resume the prior dose 2 to 3 days after stopping clarithromycin.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clarithromycin 的其他交互作用
Cabozantinib 的其他交互作用
常見問題
Can I take Cabozantinib with Clarithromycin?
MediHelp rates the interaction as major. Cabozantinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises cabozantinib exposure through CYP3A4 inhibition, which may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
How serious is the interaction between Cabozantinib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-CYP3A4-inhibiting antibiotic. If required, reduce the cabozantinib dose per labeling and resume the prior dose 2 to 3 days after stopping clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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