藥物交互作用
Capecitabine + Idecabtagene vicleucel
嚴重程度: 嚴重
Capecitabine and Idecabtagene vicleucel: major interaction.
最後更新
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摘要
Capecitabine causes myelosuppression and lymphopenia, which can add to the prolonged cytopenias and infection risk seen after CAR-T therapy. Chemotherapy given around the time of cell infusion may also impair CAR-T expansion and persistence.
用白話說明這項交互作用的意義
Capecitabine and Idecabtagene vicleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capecitabine belongs to Oncology; Idecabtagene vicleucel belongs to Oncology.
為什麼會發生
Additive myelosuppressive and immunosuppressive effects, with possible cytotoxic effects on infused T cells.
處置方式
Avoid capecitabine during lymphodepletion and the early period after CAR-T infusion unless clearly required. If used, monitor blood counts and infection signs closely and give anti-infective prophylaxis as per protocol.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Capecitabine 的其他交互作用
Idecabtagene vicleucel 的其他交互作用
常見問題
Can I take Capecitabine with Idecabtagene vicleucel?
MediHelp rates the interaction as major. Capecitabine and Idecabtagene vicleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capecitabine causes myelosuppression and lymphopenia, which can add to the prolonged cytopenias and infection risk seen after CAR-T therapy. Chemotherapy given around the time of cell infusion may also impair CAR-T expansion and persistence.
How serious is the interaction between Capecitabine and Idecabtagene vicleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid capecitabine during lymphodepletion and the early period after CAR-T infusion unless clearly required. If used, monitor blood counts and infection signs closely and give anti-infective prophylaxis as per protocol.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
