藥物交互作用
Arsenic trioxide + Capecitabine
嚴重程度: 嚴重
Arsenic trioxide and Capecitabine: major interaction.
最後更新
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摘要
Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Fluorouracil-class drugs have rare reports of cardiotoxicity, so the combination adds uncertain additional risk on top of a high baseline risk.
用白話說明這項交互作用的意義
Arsenic trioxide and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Capecitabine belongs to Oncology.
為什麼會發生
Arsenic trioxide blocks cardiac repolarization currents; capecitabine contribution to QT effect is weak and not well established.
處置方式
Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Capecitabine 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Capecitabine?
MediHelp rates the interaction as major. Arsenic trioxide and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Fluorouracil-class drugs have rare reports of cardiotoxicity, so the combination adds uncertain additional risk on top of a high baseline risk.
How serious is the interaction between Arsenic trioxide and Capecitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Capecitabine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
