藥物交互作用
Carboplatin + Dexamethasone-tobramycin
嚴重程度: 嚴重
Carboplatin and Dexamethasone-tobramycin: major interaction.
最後更新
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摘要
Carboplatin and tobramycin are both nephrotoxic and ototoxic, and combining them increases the risk of kidney injury and hearing loss. Risk is higher with renal impairment, dehydration or high cumulative doses.
用白話說明這項交互作用的意義
Carboplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Dexamethasone-tobramycin belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxic and ototoxic effects of platinum agents and aminoglycosides.
處置方式
Avoid combining if an alternative antibiotic exists; otherwise monitor serum creatinine, tobramycin levels and hearing, and ensure adequate hydration.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-tobramycin 的其他交互作用
Carboplatin 的其他交互作用
常見問題
Can I take Carboplatin with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Carboplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboplatin and tobramycin are both nephrotoxic and ototoxic, and combining them increases the risk of kidney injury and hearing loss. Risk is higher with renal impairment, dehydration or high cumulative doses.
How serious is the interaction between Carboplatin and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if an alternative antibiotic exists; otherwise monitor serum creatinine, tobramycin levels and hearing, and ensure adequate hydration.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Ciprofloxacin, Cisplatin. The full list is on the Dexamethasone-tobramycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
