藥物交互作用
Deferasirox + Dexamethasone-tobramycin
嚴重程度: 嚴重
Deferasirox and Dexamethasone-tobramycin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Deferasirox can cause kidney injury and combined use with aminoglycosides may increase this risk. Deferasirox may also modestly reduce dexamethasone exposure through CYP3A4 induction.
用白話說明這項交互作用的意義
Deferasirox and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Dexamethasone-tobramycin belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxicity; deferasirox may also induce CYP3A4.
處置方式
Monitor serum creatinine and creatinine clearance regularly, and interrupt or reduce deferasirox if renal function declines. Use tobramycin level monitoring.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dexamethasone-tobramycin 的其他交互作用
Deferasirox 的其他交互作用
常見問題
Can I take Deferasirox with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Deferasirox and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause kidney injury and combined use with aminoglycosides may increase this risk. Deferasirox may also modestly reduce dexamethasone exposure through CYP3A4 induction.
How serious is the interaction between Deferasirox and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and creatinine clearance regularly, and interrupt or reduce deferasirox if renal function declines. Use tobramycin level monitoring.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
