藥物交互作用
Clozapine + Fesoterodine
嚴重程度: 嚴重
Clozapine and Fesoterodine: major interaction.
最後更新
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摘要
Clozapine is strongly anticholinergic, and adding fesoterodine increases the risk of constipation, which with clozapine can progress to serious gastrointestinal hypomotility or ileus. Urinary retention, tachycardia and delirium may also occur.
用白話說明這項交互作用的意義
Clozapine and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
為什麼會發生
Additive antimuscarinic effects causing reduced gastrointestinal and bladder motility.
處置方式
Avoid the combination if possible; if used, monitor bowel function closely, treat constipation proactively, and review for alternatives such as a non-antimuscarinic bladder agent.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fesoterodine 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Fesoterodine?
MediHelp rates the interaction as major. Clozapine and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly anticholinergic, and adding fesoterodine increases the risk of constipation, which with clozapine can progress to serious gastrointestinal hypomotility or ileus. Urinary retention, tachycardia and delirium may also occur.
How serious is the interaction between Clozapine and Fesoterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely, treat constipation proactively, and review for alternatives such as a non-antimuscarinic bladder agent.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Levoketoconazole, Pramlintide. The full list is on the Fesoterodine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
