藥物交互作用
Fesoterodine + Thioridazine
嚴重程度: 嚴重
Fesoterodine and Thioridazine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Thioridazine has strong anticholinergic activity, so combined use markedly increases risk of dry mouth, constipation, urinary retention, confusion and tachycardia. Thioridazine is also a CYP2D6 substrate and inhibitor with a risk of QT prolongation.
用白話說明這項交互作用的意義
Fesoterodine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fesoterodine belongs to Genitourinary; Thioridazine belongs to Central Nervous System.
為什麼會發生
Additive antimuscarinic effects, with thioridazine's CYP2D6 inhibition potentially raising fesoterodine metabolite levels.
處置方式
Avoid the combination where possible, particularly in elderly patients. If unavoidable, monitor for anticholinergic toxicity and ECG changes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fesoterodine 的其他交互作用
Thioridazine 的其他交互作用
常見問題
Can I take Fesoterodine with Thioridazine?
MediHelp rates the interaction as major. Fesoterodine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine has strong anticholinergic activity, so combined use markedly increases risk of dry mouth, constipation, urinary retention, confusion and tachycardia. Thioridazine is also a CYP2D6 substrate and inhibitor with a risk of QT prolongation.
How serious is the interaction between Fesoterodine and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in elderly patients. If unavoidable, monitor for anticholinergic toxicity and ECG changes.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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