藥物交互作用
Clozapine + Oxybutynin
嚴重程度: 嚴重
Clozapine and Oxybutynin: major interaction.
最後更新
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摘要
Clozapine is highly anticholinergic, and combining it with oxybutynin raises the risk of constipation, which can progress to serious bowel hypomotility or ileus, as well as urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal complications can be severe.
用白話說明這項交互作用的意義
Clozapine and Oxybutynin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
為什麼會發生
Additive antimuscarinic effects on gut, bladder and central nervous system.
處置方式
Avoid the combination where possible; if used, monitor bowel function closely and give laxatives proactively. Reassess the need for oxybutynin and consider non-anticholinergic options for urinary symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Oxybutynin 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Oxybutynin?
MediHelp rates the interaction as major. Clozapine and Oxybutynin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is highly anticholinergic, and combining it with oxybutynin raises the risk of constipation, which can progress to serious bowel hypomotility or ileus, as well as urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal complications can be severe.
How serious is the interaction between Clozapine and Oxybutynin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor bowel function closely and give laxatives proactively. Reassess the need for oxybutynin and consider non-anticholinergic options for urinary symptoms.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Potassium chloride, Rivastigmine. The full list is on the Oxybutynin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
