藥物交互作用
Collagenase + Silver sulfadiazine
嚴重程度: 中度
Collagenase and Silver sulfadiazine: moderate interaction.
最後更新
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摘要
Silver ions released from silver sulfadiazine can inactivate collagenase applied to the same wound. This may reduce the debriding action of the enzyme and slow removal of necrotic tissue.
用白話說明這項交互作用的意義
Collagenase and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Collagenase belongs to Miscellaneous; Silver sulfadiazine belongs to Anti Bacterial.
為什麼會發生
Silver heavy metal ions denature the enzyme protein and reduce its activity.
處置方式
Avoid applying both to the same wound area at once. If silver sulfadiazine was used, cleanse the wound thoroughly before applying collagenase.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Silver sulfadiazine 的其他交互作用
常見問題
Can I take Collagenase with Silver sulfadiazine?
MediHelp rates the interaction as moderate. Collagenase and Silver sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silver ions released from silver sulfadiazine can inactivate collagenase applied to the same wound. This may reduce the debriding action of the enzyme and slow removal of necrotic tissue.
How serious is the interaction between Collagenase and Silver sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid applying both to the same wound area at once. If silver sulfadiazine was used, cleanse the wound thoroughly before applying collagenase.
What other medicines interact with Silver sulfadiazine?
MediHelp also lists interactions of Silver sulfadiazine with, for example, Allogeneic cultured keratinocytes and fibroblasts, Papain, Trypsin. The full list is on the Silver sulfadiazine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
